Application of the hottest barrier material in pha

2022-08-22
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The application of high barrier materials in the pharmaceutical packaging industry

overview

in China, the two are interdependent upstream and downstream. The outline of the "Tenth Five Year Plan" for the development of the pharmaceutical packaging industry clearly points out that the overall level of China's pharmaceutical packaging still lags behind developed countries, and the material quantity of the drug package and the contribution rate of the clamp assembly of the package is tensile machine to the pharmaceutical economy are lower than the international level. The proportion of packaging and drug value in developed countries is 15% - 20%, and some are as high as 30%; In China, it only accounts for 8% to 9%. The drug packaging, which accounts for about 65% of the total amount of preparations, has not reached the average level of the 1980s

the pharmaceutical industry is showing a trend of rapid internationalization and enterprise resource integration, and this trend will continue to develop. In the process of resource integration, enterprises expect to reduce costs, optimize the use of production equipment, reduce indirect costs, and improve the process of quickly bringing products to market. The result of its development is to promote the development of more professional, scientific, simple and reasonable packaging, processes and strategies

the State Food and drug administration is vigorously promoting the registration and management of drugs and drug packaging materials, in line with international practices, improving the international competitiveness of domestic drugs, and putting an end to the phenomenon that the same patented drugs have different names. Therefore, we must choose the right packaging materials, and enough to protect drugs. These packaging materials are not necessarily the same as the original packaging materials, because during the service life of these drugs, the materials may not be fully utilized by the API manufacturing company, and the high barrier performance of drug packaging is the most important criterion to be considered. It is the sacred mission of Jiangsu Qionghua High Tech Co., Ltd. to change the backward status of pharmaceutical packaging, adopt new technology and develop pharmaceutical high barrier packaging materials

Introduction to high barrier materials

the three recognized high barrier materials are PVDC, ev-oh, and pan (polyethylene terephthalate). The three materials are copolymers, and the barrier property to oxygen, ev-oh is better than PVDC, PVDC is better than pan; For the barrier of water vapor, ev-oh is better than PVDC, and PVDC is better than pan. However, under high humidity conditions, the barrier performance of ev-oh decreases significantly. At the same time, with the increase of environmental humidity, the barrier property of Pan materials also decreased significantly. In terms of comprehensive performance, PVDC material is the best

pvdc is poly (vinylidene chloride) 54 ordinary concrete small hollow block, which has two states, one is light yellow, powdery resin, and the other is latex like opaque liquid. By adding certain stabilizers and plasticizers to PVDC powder resin, Bayer materials technology is subordinate to Bayer Group Company to adopt extrusion blow molding. The products are mainly used for the packaging of casing film; PVDC latex is mainly coated on the surface of PVC, pet and other sheets or films. The products are mainly used in pharmaceutical blister packaging, granular powder packaging and food packaging

in addition to the general properties of plastics, high barrier composites coated with PVDC latex also have self extinguishing, oil resistance, fragrance retention, excellent moisture and mold resistance, as well as excellent printing and heat sealing properties. They are the best comprehensive barrier among many plastic packaging materials. It is not only different from ev-oh (polyvinyl alcohol) which decreases the barrier performance significantly with the increase of humidity, but also different from pan which deteriorates the barrier performance due to water absorption. It is a high barrier material with excellent moisture and gas resistance, and the environmental conditions have little influence on its barrier performance

new processing technology of PVDC coated composites

PVDC (polyvinylidene chloride) is difficult to process. Although it has excellent barrier properties, it cannot be industrialized. Therefore, the commonly called PVDC refers to the copolymerized polymer material with vinylidene chloride (VDC) as the main body. The VDC content of PVDC used in packaging industry is about 90%, and the commonly used monomers are acrylic acid, acrylate, etc. These copolymers played an internal plasticizing role, improved the processability of PVDC, and did not cause a fatal reduction in its barrier performance

pvdc processing industry began in the late 1930s and was first realized by Dow Chemical Company of the United States. At that time, it coincided with the "World War II", and PVDC was mainly used for military packaging. Later, with the rapid development of world industry, especially the food processing industry, PVDC showed extremely excellent performance in the preservation of non frozen food, the quality assurance of food and drugs, and the extension of shelf life. For decades, PVDC, as a high barrier packaging material, has always been in a leading position, although there are also ev-oh and pan materials, However, their high barrier performance has decreased significantly in high humidity environment and has not been further developed. Similarly, PA (not a strictly defined barrier material) can not replace the excellent high barrier function of PVDC for the packaging protection of contents, and the usual practice also needs to improve its packaging performance by using PVDC coating process

pvdc latex coating process flow is different from PVDC resin blowing and extrusion process. PVDC latex coating process flow:

substrate unwinding - Pretreatment - undercoat - IR and air drying - intermediate coating - IR and air drying - top coating - IR and air drying - reeling. It can be seen from the coating process that the coating of latex only involves coating and heating and drying process. There is no additional additive in the final film formation, so although the coating has only μ M thick, but its barrier performance to oxygen and wet steam is equivalent to 25 μ The barrier property of M blown film Among them, primer, IR and air drying are the proprietary new technologies of Qionghua high tech. (to be continued)

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